What this test measures
Major organ / tumour resection specimens. Comprehensive grossing, multiple-block sampling, H&E + IHC + molecular markers, CAP synoptic reporting with full TNM staging, margins, lymph node assessment, hormone receptors, and molecular profile.
Why it matters
Large resection specimens drive MDT decision-making for adjuvant therapy, prognosis, and surveillance. Comprehensive pathology reporting is the foundation of personalised cancer treatment. See HISTOPATH (LARGE) for full details.
How to prepare
Major surgery preparation — usually general anaesthetic, multi-day admission. Surgical team orients and ink-marks specimen at OT before transport in formalin to pathology.
Markers & reference ranges
Reference ranges below are typical adult values. Your lab's reported range may differ slightly based on the assay platform and patient demographics — always read your report against the range printed on it.
| Marker | Normal range | If low | If high |
|---|---|---|---|
| Full Histopathology + Staging + Molecular (CAP synoptic report)[1] | Benign with clear margins | Benign — incidental findings; routine follow-up. | Malignant — diagnosis, grade, full pTNM staging, all margins, lymph node count + positivity, hormone receptors, molecular markers (KRAS, BRAF, EGFR, ALK, MSI, BRCA where applicable) drive MDT decisions. |
Common large resections
| Specimen | Key reporting |
|---|---|
| Colectomy (cancer) | TNM, MSI, KRAS/NRAS/BRAF, LN ≥ 12 |
| Mastectomy | TNM, ER/PR/HER-2, axillary LN |
| Hysterectomy (endometrial) | TNM, myometrial invasion, MMR/MSI |
| Nephrectomy | Type, ISUP grade, TNM, vascular |
| Prostatectomy | ISUP grade, margins, LN |
| Lobectomy (lung) | TNM, EGFR/ALK/ROS1/PD-L1 |
Frequently asked questions
Is this the same as Histopath (Large)?
Yes — same comprehensive reporting standards under a different rate-card name.
How long does the report take?
Routine major resection: 7-14 days. Complex molecular cases: 2-3 weeks.
Why so many molecular tests?
Each guides a specific treatment decision — MSI for immunotherapy, KRAS/NRAS/BRAF for chemo selection, HER-2 for trastuzumab, EGFR/ALK/ROS1 for targeted lung-cancer drugs, BRCA for PARP inhibitor.
What is synoptic reporting?
Standardised CAP-style structured report ensuring all required elements are captured.
Related Histopathology / Cytology tests
Tests commonly ordered alongside Histopathology Biopsy: Large Specimen, or that help interpret an unexpected result.
Sources & references
- Royal College of Pathologists · accessed 2026-05-30T00:00:00.000Z
- CAP — Cancer Protocols · accessed 2026-05-30T00:00:00.000Z
- WHO Classification of Tumours · accessed 2026-05-30T00:00:00.000Z
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